Otero Museum is home to the Sciumbato Store and Dwelling (listed on the National Registry of Historical Sites), which served as a neighborhood grocery for almost seventy years.

The U.L. Hiatt building serves as the museum entrance and houses the Fine Art League Loft, the reproduction of a 1920s filling station complete with gasoline pumps and a vintage 1916 Dodge touring car. Other displays in the Hiatt Building are restored tractors, a 1880s type Reaper, the first 1954 fire engine purchased by the Rural Fire Department (1953), and momentos of the Civil War, World War I, and World War II.

The H. L. & Louise Boyd Coach House contains the original Concord State Coach 106 built in Concord, New Hampshire in 1865. It saw service between Atchison, Kansas and Denver until the railroad put it out of business. It was later used in other areas around the mining camps of Leadville. Also in the Boyd Building are the first cars in La Junta: a 1905 Reo "side winder," a 1916 chuck wagon, an early 1900s surrey with fringe on top, collections of barbed wire and arrowheads, and tools used in ranching and farming. The collection includes ox shoes and early day saddles, including one used by one of Pancho Villa's generals in the 1916 war between the U.S. and Mexico.